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Air pollution and lung cancer incidence in 17 European cohorts : prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Raaschou-Nielsen, Ole and Andersen, Zorana J. and Beelen, Rob and Samoli, Evangelia and Stafoggia, Massimo and Weinmayr, Gudrun and Hoffmann, Barbara and Fischer, Paul and Nieuwenhuijsen, Mark J. and Brunekreef, Bert and Xun, Wei W. and Katsouyanni, Klea and Dimakopoulou, Konstantina and Sommar, Johan and Forsberg, Bertil and Modig, Lars and Oudin, Anna and Oftedal, Bente and Schwarze, Per E. and Nafstad, Per and De Faire, Ulf and Pedersen, Nancy L. and Ostenson, Claes-Göran and Fratiglioni, Laura and Penell, Johanna and Korek, Michal and Pershagen, Göran and Eriksen, Kirsten T. and Sørensen, Mette and Tjønneland, Anne and Ellermann, Thomas and Eeftens, Marloes and Peeters, Petra H. and Meliefste, Kees and Wang, Meng and Bueno-de-Mesquita, Bas and Key, Timothy J. and de Hoogh, Kees and Concin, Hans and Nagel, Gabriele and Vilier, Alice and Grioni, Sara and Krogh, Vittorio and Tsai, Ming-Yi and Ricceri, Fulvio and Sacerdote, Carlotta and Galassi, Claudia and Migliore, Enrica and Ranzi, Andrea and Cesaroni, Giulia and Badaloni, Chiara and Forastiere, Francesco and Tamayo, Ibon and Amiano, Pilar and Dorronsoro, Miren and Trichopoulou, Antonia and Bamia, Christina and Vineis, Paolo and Hoek, Gerard. (2013) Air pollution and lung cancer incidence in 17 European cohorts : prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE). The Lancet oncology, Vol. 14, H. 9. pp. 813-822.

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Official URL: http://edoc.unibas.ch/dok/A6165162

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Abstract

Ambient air pollution is suspected to cause lung cancer. We aimed to assess the association between long-term exposure to ambient air pollution and lung cancer incidence in European populations.; This prospective analysis of data obtained by the European Study of Cohorts for Air Pollution Effects used data from 17 cohort studies based in nine European countries. Baseline addresses were geocoded and we assessed air pollution by land-use regression models for particulate matter (PM) with diameter of less than 10 μm (PM10), less than 2·5 μm (PM2·5), and between 2·5 and 10 μm (PMcoarse), soot (PM2·5absorbance), nitrogen oxides, and two traffic indicators. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effects models for meta-analyses.; The 312 944 cohort members contributed 4 013 131 person-years at risk. During follow-up (mean 12·8 years), 2095 incident lung cancer cases were diagnosed. The meta-analyses showed a statistically significant association between risk for lung cancer and PM10 (hazard ratio [HR] 1·22 [95% CI 1·03-1·45] per 10 μg/m(3)). For PM2·5 the HR was 1·18 (0·96-1·46) per 5 μg/m(3). The same increments of PM10 and PM2·5 were associated with HRs for adenocarcinomas of the lung of 1·51 (1·10-2·08) and 1·55 (1·05-2·29), respectively. An increase in road traffic of 4000 vehicle-km per day within 100 m of the residence was associated with an HR for lung cancer of 1·09 (0·99-1·21). The results showed no association between lung cancer and nitrogen oxides concentration (HR 1·01 [0·95-1·07] per 20 μg/m(3)) or traffic intensity on the nearest street (HR 1·00 [0·97-1·04] per 5000 vehicles per day).; Particulate matter air pollution contributes to lung cancer incidence in Europe.; European Community's Seventh Framework Programme.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Eeftens, Marloes and Tsai, Ming
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1470-2045
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:31 Jan 2014 09:50
Deposited On:31 Jan 2014 09:50

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