Inflammatory response and IgE sensitization at early age

Mustonen, Kirsi and Orivuori, Laura and Keski-Nisula, Leea and Hyvärinen, Anne and Pfefferle, Petra Ina and Riedler, Josef and Dalphin, Jean-Charles and Genuneit, Jon and Lauener, Roger and Roduit, Caroline and Braun-Fahrländer, Charlotte and Weber, Juliane and Schaub, Bianca and von Mutius, Erika and Pekkanen, Juha and Vaarala, Outi and Pasture Study Group, . (2013) Inflammatory response and IgE sensitization at early age. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Clinical Immunology, Vol. 24, H. 4. pp. 395-401.

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Official URL: http://edoc.unibas.ch/dok/A6165028

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Microbial exposure may induce low-grade inflammation at an early age and decrease the risk of allergic diseases, as suggested by the hygiene hypothesis. We examined the associations between low-grade inflammation and the development of allergic sensitization, atopic dermatitis (AD), and asthma at the age of 4.5 yr.; We studied 636 children participating in the PASTURE study in Finland, Germany, Austria, France, and Switzerland. Data of environmental factors, doctor-diagnosed AD, and asthma were collected by questionnaire. The serum high-sensitivity C-reactive protein (CRP) values were measured at the age of 1 yr, and serum-specific IgE concentrations (sIgE) at the age of one and 4.5 yr. Analyses were made by logistic regression analysis.; The risk of allergic sensitization at the age of 4.5 yr was decreased in children who had increased CRP levels at the age of 1 yr (level in the highest vs. lowest quartile: aOR 0.48, 95% CI 0.24-0.95; p = 0.014). The risk of AD and asthma was not significantly related to CRP.; The findings confirm that elevated levels of CRP at early age showed association with decreased allergic sensitization later in life. Our results suggest that poor inflammatory response could predispose for IgE sensitization.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Microbial Exposure & Childhood Allergies (Braun-Fahrländer)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Braun-Fahrländer, Charlotte
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:31 Jan 2014 09:49
Deposited On:31 Jan 2014 09:49

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