Where is mTOR and what is it doing there?

Betz, C. and Hall, M. N.. (2013) Where is mTOR and what is it doing there? Journal of cell biology, Vol. 203, H. 4. pp. 563-574.

PDF - Published Version
Available under License CC BY-NC-SA (Attribution-NonCommercial-ShareAlike).


Official URL: http://edoc.unibas.ch/dok/A6205319

Downloads: Statistics Overview


Target of rapamycin (TOR) forms two conserved, structurally distinct kinase complexes termed TOR complex 1 (TORC1) and TORC2. Each complex phosphorylates a different set of substrates to regulate cell growth. In mammals, mTOR is stimulated by nutrients and growth factors and inhibited by stress to ensure that cells grow only during favorable conditions. Studies in different organisms have reported localization of TOR to several distinct subcellular compartments. Notably, the finding that mTORC1 is localized to the lysosome has significantly enhanced our understanding of mTORC1 regulation. Subcellular localization may be a general principle used by TOR to enact precise spatial and temporal control of cell growth.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall)
UniBasel Contributors:Hall, Michael N.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Rockefeller University Press
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
edoc DOI:
Last Modified:31 Dec 2015 10:54
Deposited On:31 Jan 2014 09:49

Repository Staff Only: item control page