edoc

TET2 promoter methylation in low-grade diffuse gliomas lacking IDH1/2 mutations

Kim, Young-Ho and Pierscianek, Daniela and Mittelbronn, Michel and Vital, Anne and Mariani, Luigi and Hasselblatt, Martin and Ohgaki, Hiroko. (2011) TET2 promoter methylation in low-grade diffuse gliomas lacking IDH1/2 mutations. Journal of clinical pathology, Vol. 64, no. 10. pp. 850-852.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6005903

Downloads: Statistics Overview

Abstract

Miscoding mutations of the TET2 gene, which encodes the ?-ketoglutarate-dependent enzyme that catalyses the conversion of 5-methylcytosine to 5-hydroxymethylcytosine, thus producing DNA demethylation, have been detected in 10-25% of acute myeloid leukaemias lacking IDH1/2 mutations. Most low-grade diffuse gliomas carry IDH1/2 mutations (<85%), but molecular mechanisms of pathogenesis in those lacking IDH1/2 mutations remain to be elucidated.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Brain Tumor Biology (Mariani)
UniBasel Contributors:Mariani, Luigi
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:British Medical Association
ISSN:0021-9746
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:31 Jan 2014 09:49
Deposited On:31 Jan 2014 09:49

Repository Staff Only: item control page