Surviving the Macrophage: Tools and Tricks Employed by Mycobacterium tuberculosis

Jayachandran, R. and Bosedasgupta, S. and Pieters, J.. (2012) Surviving the Macrophage: Tools and Tricks Employed by Mycobacterium tuberculosis. Current topics in microbiology and immunology, Vol. 374. pp. 189-209.

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Official URL: http://edoc.unibas.ch/dok/A6070209

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Mycobacterium tuberculosis has evolved to withstand one of the most inhospitable cells within the human body, namely the macrophage, a cell that is normally geared toward the destruction of any invading microbe. How M. tuberculosis achieves this is still incompletely understood; however, a number of mechanisms are now known that provide advantages to M. tuberculosis for its survival and proliferation inside the macrophage. While some of these mechanisms are mediated by factors released by M. tuberculosis, others rely on host components that are being hijacked to benefit survival of M. tuberculosis within the macrophage as well to avoid the generation of an effective immune response. Here, we describe several of these mechanisms, also pointing out the potential usage of this knowledge toward the development of novel strategies to treat tuberculosis. Furthermore, we attempt to put the 'macrophage niche' into context with other intracellular pathogens and discuss some of the generalities as well as specializations that M. tuberculosis employs to survive.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Biochemistry (Pieters)
UniBasel Contributors:Pieters, Jean
Item Type:Article, refereed
Article Subtype:Research Article
Note:Also published in: Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism. - Heidelberg : Springer. - S. 189-209 -- Publication type according to Uni Basel Research Database: Journal article
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Last Modified:03 Jan 2014 08:49
Deposited On:03 Jan 2014 08:49

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