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GRADE guidelines: 3. Rating the quality of evidence

Balshem, Howard and Helfand, Mark and Schünemann, Holger J. and Oxman, Andrew D. and Kunz, Regina and Brozek, Jan and Vist, Gunn E. and Falck-Ytter, Yngve and Meerpohl, Joerg and Norris, Susan and Guyatt, Gordon H.. (2011) GRADE guidelines: 3. Rating the quality of evidence. Journal of clinical epidemiology, Vol. 64, H. 4. pp. 401-406.

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Official URL: http://edoc.unibas.ch/dok/A6006970

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Abstract

This article introduces the approach of GRADE to rating quality of evidence. GRADE specifies four categories-high, moderate, low, and very low-that are applied to a body of evidence, not to individual studies. In the context of a systematic review, quality reflects our confidence that the estimates of the effect are correct. In the context of recommendations, quality reflects our confidence that the effect estimates are adequate to support a particular recommendation. Randomized trials begin as high-quality evidence, observational studies as low quality. "Quality" as used in GRADE means more than risk of bias and so may also be compromised by imprecision, inconsistency, indirectness of study results, and publication bias. In addition, several factors can increase our confidence in an estimate of effect. GRADE provides a systematic approach for considering and reporting each of these factors. GRADE separates the process of assessing quality of evidence from the process of making recommendations. Judgments about the strength of a recommendation depend on more than just the quality of evidence.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Versicherungsmedizin > Versicherungsmedizin (Kunz)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Versicherungsmedizin > Versicherungsmedizin (Kunz)
UniBasel Contributors:Kunz, Regina
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Pergamon Press
ISSN:0895-4356
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:06 Dec 2013 09:36
Deposited On:06 Dec 2013 09:36

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