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GRADE guidelines: 9. Rating up the quality of evidence

Guyatt, Gordon H. and Oxman, Andrew D. and Sultan, Shahnaz and Glasziou, Paul and Akl, Elie A. and Alonso-Coello, Pablo and Atkins, David and Kunz, Regina and Brozek, Jan and Montori, Victor and Jaeschke, Roman and Rind, David and Dahm, Philipp and Meerpohl, Joerg and Vist, Gunn and Berliner, Elise and Norris, Susan and Falck-Ytter, Yngve and Murad, M. Hassan and Schünemann, Holger J. and Grade Working Group, . (2011) GRADE guidelines: 9. Rating up the quality of evidence. Journal of clinical epidemiology, Vol. 64, H. 12. pp. 1311-1316.

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Official URL: http://edoc.unibas.ch/dok/A6006440

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Abstract

The most common reason for rating up the quality of evidence is a large effect. GRADE suggests considering rating up quality of evidence one level when methodologically rigorous observational studies show at least a two-fold reduction or increase in risk, and rating up two levels for at least a five-fold reduction or increase in risk. Systematic review authors and guideline developers may also consider rating up quality of evidence when a dose-response gradient is present, and when all plausible confounders or biases would decrease an apparent treatment effect, or would create a spurious effect when results suggest no effect. Other considerations include the rapidity of the response, the underlying trajectory of the condition, and indirect evidence.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Versicherungsmedizin > Versicherungsmedizin (Kunz)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Versicherungsmedizin > Versicherungsmedizin (Kunz)
UniBasel Contributors:Kunz, Regina
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Pergamon Press
ISSN:0895-4356
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:06 Dec 2013 09:36
Deposited On:06 Dec 2013 09:36

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