Guyatt, Gordon H. and Oxman, Andrew D. and Montori, Victor and Vist, Gunn and Kunz, Regina and Brozek, Jan and Alonso-Coello, Pablo and Djulbegovic, Ben and Atkins, David and Falck-Ytter, Yngve and Williams, John W. and Meerpohl, Joerg and Norris, Susan L. and Akl, Elie A. and Schünemann, Holger J.. (2011) GRADE guidelines: 5. Rating the quality of evidence-publication bias. Journal of clinical epidemiology, Vol. 64, H. 12. pp. 1277-1282.
Full text not available from this repository.
Official URL: http://edoc.unibas.ch/dok/A6004113
Downloads: Statistics Overview
Abstract
In the GRADE approach, randomized trials start as high-quality evidence and observational studies as low-quality evidence, but both can be rated down if a body of evidence is associated with a high risk of publication bias. Even when individual studies included in best-evidence summaries have a low risk of bias, publication bias can result in substantial overestimates of effect. Authors should suspect publication bias when available evidence comes from a number of small studies, most of which have been commercially funded. A number of approaches based on examination of the pattern of data are available to help assess publication bias. The most popular of these is the funnel plot; all, however, have substantial limitations. Publication bias is likely frequent, and caution in the face of early results, particularly with small sample size and number of events, is warranted.
Faculties and Departments: | 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Versicherungsmedizin > Versicherungsmedizin (Kunz) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Versicherungsmedizin > Versicherungsmedizin (Kunz) |
---|---|
UniBasel Contributors: | Kunz, Regina |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Pergamon Press |
ISSN: | 0895-4356 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Identification Number: | |
Last Modified: | 06 Dec 2013 09:36 |
Deposited On: | 06 Dec 2013 09:36 |
Repository Staff Only: item control page