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GRADE guidelines: 2. Framing the question and deciding on important outcomes

Guyatt, Gordon H. and Oxman, Andrew D. and Kunz, Regina and Atkins, David and Brozek, Jan and Vist, Gunn and Alderson, Philip and Glasziou, Paul and Falck-Ytter, Yngve and Schünemann, Holger J.. (2011) GRADE guidelines: 2. Framing the question and deciding on important outcomes. Journal of clinical epidemiology, Vol. 64, H. 4. pp. 395-400.

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Official URL: http://edoc.unibas.ch/dok/A6003756

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Abstract

GRADE requires a clear specification of the relevant setting, population, intervention, and comparator. It also requires specification of all important outcomes-whether evidence from research studies is, or is not, available. For a particular management question, the population, intervention, and outcome should be sufficiently similar across studies that a similar magnitude of effect is plausible. Guideline developers should specify the relative importance of the outcomes before gathering the evidence and again when evidence summaries are complete. In considering the importance of a surrogate outcome, authors should rate the importance of the patient-important outcome for which the surrogate is a substitute and subsequently rate down the quality of evidence for indirectness of outcome.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Versicherungsmedizin > Versicherungsmedizin (Kunz)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Versicherungsmedizin > Versicherungsmedizin (Kunz)
UniBasel Contributors:Kunz, Regina
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Pergamon Press
ISSN:0895-4356
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:06 Dec 2013 09:36
Deposited On:06 Dec 2013 09:36

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