Performance of the Xpert® MTB/RIF assay in an active case-finding strategy : a pilot study from Tanzania

Ntinginya, E. N. and Squire, S. B. and Millington, K. A. and Mtafya, B. and Saathoff, E. and Heinrich, N. and Rojas-Ponce, G. and Kowuor, D. and Maboko, L. and Reither, K. and Clowes, P. and Hoelscher, M. and Rachow, A.. (2012) Performance of the Xpert® MTB/RIF assay in an active case-finding strategy : a pilot study from Tanzania. The international journal of tuberculosis and lung disease : the official journal of the International Union Against Tuberculosis and Lung Disease, Vol. 16, H. 11. pp. 1468-1470.

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Official URL: http://edoc.unibas.ch/dok/A6164948

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In this pilot study, we evaluated the Xpert((R)) MTB/RIF assay in an active case-finding strategy, using two spot sputum samples collected within a 1-hour interval from household contacts of smear-positive TB index cases. Tuberculosis (TB) confirmed by culture served as the reference standard. Among 219 enrolled contacts, the yield of active TB was 2.3%. While the sensitivity of smear microscopy was 60% (95%CI 14.7-94.7), Xpert MTB/RIF achieved a sensitivity of 100% (95%CI 47.81-100.0). All culture-confirmed cases tested positive by Xpert MTB/RIF on the first submitted sample, suggesting that the evaluation of only one sample could be sufficient for TB diagnosis in this context
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Tuberculosis Ecology and Evolution Unit (Gagneux)
UniBasel Contributors:Reither, Klaus
Item Type:Article, refereed
Article Subtype:Book Review
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:06 Dec 2013 09:35
Deposited On:06 Dec 2013 09:35

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