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Rac1 deletion causes thymic atrophy

Hunziker, Lukas and Benitah, Salvador Aznar and Aznar Benitah, Salvador and Braun, Kristin M. and Jensen, Kim and McNulty, Katrina and Butler, Colin and Potton, Elspeth and Nye, Emma and Boyd, Richard and Laurent, Geoff and Glogauer, Michael and Wright, Nick A. and Watt, Fiona M. and Janes, Sam M.. (2011) Rac1 deletion causes thymic atrophy. PLoS ONE, Vol. 6, H. 4 , e19292.

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Official URL: http://edoc.unibas.ch/dok/A6006473

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Abstract

The thymic stroma supports T lymphocyte development and consists of an epithelium maintained by thymic epithelial progenitors. The molecular pathways that govern epithelial homeostasis are poorly understood. Here we demonstrate that deletion of Rac1 in Keratin 5/Keratin 14 expressing embryonic and adult thymic epithelial cells leads to loss of the thymic epithelial compartment. Rac1 deletion led to an increase in c-Myc expression and a generalized increase in apoptosis associated with a decrease in thymic epithelial proliferation. Our results suggest Rac1 maintains the epithelial population, and equilibrium between Rac1 and c-Myc may control proliferation, apoptosis and maturation of the thymic epithelial compartment. Understanding thymic epithelial maintenance is a step toward the dual goals of in vitro thymic epithelial cell culture and T cell differentiation, and the clinical repair of thymic damage from graft-versus-host-disease, chemotherapy or irradiation.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Pneumologie > Pneumologie (Tamm)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Pneumologie > Pneumologie (Tamm)
UniBasel Contributors:Hunziker Munsch, Lukas Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Public Library of Science
e-ISSN:1932-6203
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:31 Aug 2018 06:40
Deposited On:06 Dec 2013 09:35

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