MAGE-A and NY-ESO-1 expression in cervical cancer : prognostic factors and effects of chemotherapy

Napoletano, C. and Bellati, F. and Tarquini, E. and Tomao, F. and Taurino, F. and Spagnoli, G. and Rughetti, A. and Muzii, L. and Nuti, M. and Benedetti Panici, P.. (2008) MAGE-A and NY-ESO-1 expression in cervical cancer : prognostic factors and effects of chemotherapy. American journal of obstetrics and gynecology, Vol. 198, H. 1 , S. 99.e1-99.e7.

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Official URL: http://edoc.unibas.ch/dok/A6004283

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OBJECTIVE: The aim of this study was to evaluate the prevalence of cancer testis tumor-associated antigens MAGE-A and NY-ESO-1 in cervical cancer and correlate expression patterns with clinicopathologic parameters and prognosis. STUDY DESIGN: One hundred sixty-two cervical cancer samples from 109 patients who were treated with radical hysterectomy, neoadjuvant chemotherapy, or pelvic disease recurrence were analyzed by immunohistochemistry. RESULTS: MAGE-A was expressed by 32/94 (34%) and 7/15 (47%) previously untreated and recurrent tumors, respectively. NY-ESO-1 was expressed by 46/94 (49%) and 6/15 (40%) previously untreated and recurrent tumors, respectively. MAGE-A in early stage tumors was correlated to tumor size and lymph node metastases (P = .024 and P = .046, respectively) whereas NY-ESO-1 to tumor grading (P = .039). CONCLUSION: Cervical cancer frequently expresses cancer testis tumor-associated antigens. MAGE-A and NY-ESO-1 expression rates are not influenced by systemic therapies. Cancer testis tumor-associated antigens are correlated to common prognostic factors.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Oncology Surgery (Spagnoli)
UniBasel Contributors:Spagnoli, Giulio C.
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Nov 2013 08:29
Deposited On:08 Nov 2013 08:29

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