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Dickkopf-3 as a new potential marker for neoangiogenesis in colorectal cancer : expression in cancer tissue and adjacent non-cancerous tissue

Zitt, Matthias and Untergasser, Gerold and Amberger, Albert and Moser, Patrizia and Stadlmann, Sylvia and Zitt, Marion and Müller, Hannes M. and Mühlmann, Gilbert and Perathoner, Alexander and Margreiter, Raimund and Gunsilius, Eberhard and Ofner, Dietmar. (2008) Dickkopf-3 as a new potential marker for neoangiogenesis in colorectal cancer : expression in cancer tissue and adjacent non-cancerous tissue. Disease markers, Vol. 24, H. 2. pp. 101-109.

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Official URL: http://edoc.unibas.ch/dok/A6005099

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Abstract

Gene expression of Dickkopf-3 (Dkk-3) has been shown to be upregulated in tumor endothelium of colorectal cancer (CRC). For the first time, we analyzed Dkk-3 protein expression in CRC and its potential as a marker for neoangiogenesis. We used tissue microarrays (TMAs) to investigate Dkk-3 in microvessels of 403 CRC samples, 318 appropriate adjacent non-cancerous samples and 127 normal colorectal samples. Of cancer samples with CD31-positive microvessels, 67.7% were positive for Dkk-3. Dkk-3 staining was demonstrated in endothelial cells of all microvessels in nearly all cases. Dkk-3-positive samples showed a higher mean microvessel count than did Dkk-3-negative samples (P=0.001). Dkk-3 expression increased with rising numbers of microvessels per sample (P>0.0001). In adjacent samples with CD31-positive microvessels, 56% were Dkk-3-positive in all microvessels. Similar to cancer samples, Dkk-3-positive adjacent samples had a higher mean microvessel count than did Dkk-3-negative samples (P>0.0001), and Dkk-3 expression also increased with rising numbers of microvessels (P>0.0001). All microvessels in normal mucosa samples were negative for Dkk-3. Dkk-3 can be considered a putative pro-angiogenic protein in neovascularization and may possibly be a marker for neoangiogenesis in CRC. Further investigations will elucidate whether Dkk-3 is a target structure for novel therapies.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB
UniBasel Contributors:Stadlmann, Sylvia
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:John Wiley
ISSN:0278-0240
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Nov 2013 08:29
Deposited On:08 Nov 2013 08:29

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