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From biomolecular structure to functional understanding : new NMR developments narrow the gap

Grzesiek, S. and Sass, H. J.. (2009) From biomolecular structure to functional understanding : new NMR developments narrow the gap. Current Opinion in Structural Biology, 19 (5). pp. 585-595.

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Official URL: http://edoc.unibas.ch/dok/A5258751

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Abstract

Biomolecular structure provides the framework for dynamics and function. However, the information of more than 50000 protein and nucleic acid structures solved today has not yet yielded enough insight such that function could be predicted from structure or that structures and dynamics could be predicted to high resolution from sequence alone. Further experimental information is urgently needed to guide the process of relating sequence, structure, dynamics, and ultimately function. Recent progress in solution NMR methods encompasses better detection of dynamics and molecular interactions, a more detailed characterization of folding transitions, increases of the molecular weight limit and sensitivity, strongly enhanced computational approaches, and the in-cell detection of molecules. These developments are highly complementary and narrow the gap between structure and functional understanding. This article discusses recent advances and applications.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Structural Biology (Grzesiek)
UniBasel Contributors:Grzesiek, Stephan
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0959-440X
e-ISSN:1879-033X
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:23 Nov 2017 15:11
Deposited On:22 Mar 2012 13:20

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