Minor sarcoplasmic reticulum membrane components that modulate excitation–contraction coupling in striated muscles

Treves, Susan and Vukcevic, Mirko and Maj, Marcin and Thurnheer, Raphael and Mosca, Barbara and Zorzato, Francesco. (2009) Minor sarcoplasmic reticulum membrane components that modulate excitation–contraction coupling in striated muscles. Journal of Physiology, 587 (13). pp. 3071-3079.

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Official URL: http://edoc.unibas.ch/dok/A6174332

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In striated muscle, activation of contraction is initiated by membrane depolarisation caused by an action potential, which triggers the release of Ca2+ stored in the sarcoplasmic reticulum by a process called excitation–contraction coupling. Excitation–contraction coupling occurs via a highly sophisticated supramolecular signalling complex at the junction between the sarcoplasmic reticulum and the transverse tubules. It is generally accepted that the core components of the excitation–contraction coupling machinery are the dihydropyridine receptors, ryanodine receptors and calsequestrin, which serve as voltage sensor, Ca2+ release channel, and Ca2+ storage protein, respectively. Nevertheless, a number of additional proteins have been shown to be essential both for the structural formation of the machinery involved in excitation–contraction coupling and for its fine tuning. In this review we discuss the functional role of minor sarcoplasmic reticulum protein components. The definition of their roles in excitation–contraction coupling is important in order to understand how mutations in genes involved in Ca2+ signalling cause neuromuscular disorders.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Perioperative Patient Safety (Girard/Treves)
UniBasel Contributors:Treves, Susan
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:31 May 2017 10:06
Deposited On:25 Oct 2013 08:33

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