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Activation of endoplasmic reticulum stress response by hepatitis viruses up-regulates protein phosphatase 2A

Christen, Verena and Treves, Susan and Duong, Francois H. T. and Heim, Markus H.. (2007) Activation of endoplasmic reticulum stress response by hepatitis viruses up-regulates protein phosphatase 2A. Hepatology, 46 (2). pp. 558-565.

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Official URL: http://edoc.unibas.ch/dok/A6174310

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Abstract

The up-regulation of protein phosphatase 2 A (PP2A) is an important factor leading to an inhibition of IFNalpha signaling caused by viral protein expression. Here, we describe the molecular mechanism involved in PP2Ac up-regulation by HCV and HBV. HCV and HBV protein expression in cells induces an ER stress response leading to calcium release from the ER. HCV protein expression induces CREB activation, probably through calcium/calmodulin-dependent protein kinase. CREB binds to a CRE element in the promoter of PP2Ac and induces its transcriptional up-regulation. Because PP2Ac is involved in many important cellular processes including cell-cycle regulation, apoptosis, cell morphology, development, signal transduction and translation, its up-regulation during ER stress has potentially important implications.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Perioperative Patient Safety (Girard/Treves)
UniBasel Contributors:Treves, Susan
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:0270-9139
e-ISSN:1527-3350
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:31 May 2017 09:16
Deposited On:25 Oct 2013 08:33

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