Investigating air pollution and atherosclerosis in humans : concepts and outlook

Künzli, Nino and Perez, Laura and von Klot, Stephanie and Baldassarre, Damiano and Bauer, Marcus and Basagana, Xavier and Breton, Carrie and Dratva, Julia and Elosua, Roberto and de Faire, Ulf and Fuks, Kateryna and de Groot, Eric and Marrugat, Jaume and Penell, Johanna and Seissler, Jochen and Peters, Annette and Hoffmann, Barbara. (2011) Investigating air pollution and atherosclerosis in humans : concepts and outlook. Progress in cardiovascular diseases, Vol. 53, H. 5. pp. 334-343.

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Official URL: http://edoc.unibas.ch/dok/A6007375

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Although ambient particulate matter contributes to atherosclerosis in animal models, its role in atherogenesis in humans needs to be established. This article discusses concepts, study design, and choice of health outcomes to efficiently investigate the atherogenic role of ambient air pollution, with an emphasis on early preclinical biomarkers of atherosclerosis that are unaffected by short-term exposure to air pollution (eg, carotid intima-media thickness [CIMT] and functional performance of the vessel). Air pollution studies using these end points are summarized. The CIMT is currently the most frequently used outcome in this field (6 studies). The continuous nature of CIMT, the lack of short-term variation, its relationship to atherosclerotic changes in the artery wall, its predictive value for coronary heart disease, and the noninvasiveness of the assessment make it a useful candidate for cross-sectional and longitudinal studies investigating the role of air pollution in atherogenesis.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin
UniBasel Contributors:Dratva, Julia and Künzli, Nino
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:Grune & Stratton
Note:Publication type according to Uni Basel Research Database: Journal item
Last Modified:31 Jul 2018 10:14
Deposited On:25 Oct 2013 08:33

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