edoc

Long-term course of lung clearance index between infancy and school-age in cystic fibrosis subjects

Kieninger, Elisabeth and Singer, Florian and Fuchs, Oliver and Abbas, Chiara and Frey, Urs and Regamey, Nicolas and Casaulta, Carmen and Latzin, Philipp. (2011) Long-term course of lung clearance index between infancy and school-age in cystic fibrosis subjects. Journal of cystic fibrosis, Vol. 10, H. 6. pp. 487-490.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6003342

Downloads: Statistics Overview

Abstract

Multiple breath washout (MBW) measurements have recently been shown to be sensitive for detection of early cystic fibrosis (CF) lung disease, with the lung clearance index (LCI) being the most common measure for ventilation inhomogeneity. The aim of this observational study was to describe the longitudinal course of LCI from time of clinical diagnosis during infancy to school-age in eleven children with CF. Elevated LCI during infancy was present in seven subjects, especially in those with later clinical diagnosis. Tracking of LCI at follow-up was evident only in the four most severe cases. We provide the first longitudinal data describing the long-term course of LCI in a small group of infants with CF. Our findings support the clinical usefulness of MBW measurements to detect and monitor early lung disease in children with CF already present shortly after clinical diagnosis.
Faculties and Departments:03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > P├Ądiatrie (Frey)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > P├Ądiatrie (Frey)
UniBasel Contributors:Frey, Urs Peter
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1569-1993
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:25 Oct 2013 08:32
Deposited On:25 Oct 2013 08:32

Repository Staff Only: item control page