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Long-term anticoagulation treatment for acute venous thromboembolism in patients with and without cancer : the SWIss Venous ThromboEmbolism Registry (SWIVTER) II

Spirk, D. and Ugi, J. and Korte, W. and Husmann, M. and Hayoz, D. and Baldi, T. and Frauchiger, B. and Banyai, M. and Aujesky, D. and Baumgartner, I. and Kucher, N.. (2011) Long-term anticoagulation treatment for acute venous thromboembolism in patients with and without cancer : the SWIss Venous ThromboEmbolism Registry (SWIVTER) II. Thrombosis and haemostasis, Vol. 105, H. 6. pp. 962-967.

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Official URL: http://edoc.unibas.ch/dok/A6003316

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Abstract

In patients with acute cancer-associated thrombosis, current consensus guidelines recommend anticoagulation therapy for an indefinite duration or until the cancer is resolved. Among 1,247 patients with acute venous thromboembolism (VTE) enrolled in the prospective Swiss Venous Thromboembolism Registry (SWIVTER) II from 18 hospitals, 315 (25%) had cancer of whom 179 (57%) had metastatic disease, 159 (50%) ongoing or recent chemotherapy, 83 (26%) prior cancer surgery, and 63 (20%) recurrent VTE. Long-term anticoagulation treatment for <12 months was more often planned in patients with versus without cancer (47% vs. 19%; p>0.001), with recurrent cancer-associated versus first cancer-associated VTE (70% vs. 41%; p>0.001), and with metastatic versus non-metastatic cancer (59% vs. 31%; p>0.001). In patients with cancer, recurrent VTE (OR 3.46; 95%CI 1.83-6.53), metastatic disease (OR 3.04; 95%CI 1.86-4.97), and the absence of an acute infection (OR 3.55; 95%CI 1.65-7.65) were independently associated with the intention to maintain anticoagulation for <12 months. In conclusion, long-term anticoagulation treatment for more than 12 months was planned in less than half of the cancer patients with acute VTE. The low rates of long-term anticoagulation in cancer patients with a first episode of VTE and in patients with non-metastatic cancer require particular attention.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Angiologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Angiologie
UniBasel Contributors:Frauchiger, Beat
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Schattauer
ISSN:0340-6245
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:25 Oct 2013 08:32
Deposited On:25 Oct 2013 08:32

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