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Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles

Kiss, Elina A. and Vonarbourg, Cedric and Kopfmann, Stefanie and Hobeika, Elias and Finke, Daniela and Esser, Charlotte and Diefenbach, Andreas. (2011) Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science, 334 (6062). pp. 1561-1565.

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Official URL: http://edoc.unibas.ch/dok/A6004031

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Abstract

Innate lymphoid cells (ILC) expressing the transcription factor ROR?t induce the postnatal formation of intestinal lymphoid follicles and regulate intestinal homeostasis. ROR?t(+) ILC express the aryl hydrocarbon receptor (AhR), a highly conserved, ligand-inducible transcription factor believed to control adaptation of multicellular organisms to environmental challenges. We show that AhR is required for the postnatal expansion of intestinal ROR?t(+) ILC and the formation of intestinal lymphoid follicles. AhR activity within ROR?t(+) ILC could be induced by dietary ligands such as those contained in vegetables of the family Brassicaceae. AhR-deficient mice were highly susceptible to infection with Citrobacter rodentium, a mouse model for attaching and effacing infections. Our results establish a molecular link between nutrients and the formation of immune system components required to maintain intestinal homeostasis and resistance to infections.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Children's Hospital > Developmental Immunology (Finke)
03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Molekulare Medizin in der P├Ądiatrie (Finke)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Molekulare Medizin in der P├Ądiatrie (Finke)
UniBasel Contributors:Finke, Daniela
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association for the Advancement of Science
ISSN:0036-8075
e-ISSN:1095-9203
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:05 Oct 2017 09:48
Deposited On:25 Oct 2013 08:32

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