Inhibition of renin in the primate Callithrix jacchus (common marmoset)

Hofbauer, K. G. and Menard, J. and Michel, J. B. and Wood, J. M.. (1983) Inhibition of renin in the primate Callithrix jacchus (common marmoset). Clinical and Experimental Hypertension. Part A, Theory and Practice, Vol. 5, H. 7-8. pp. 1237-1247.

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Official URL: http://edoc.unibas.ch/dok/A5258677

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The effects of an antiserum against human kidney renin and of H-142, a peptide inhibitor of human renin, were studied in the primate Callithrix jacchus (common marmoset). In severely volume-depleted (low-salt diet and repetitive injections of furosemide), conscious marmosets, the antiserum reduced blood pressure to the same extent as the converting enzyme inhibitor teprotide (-31 +/- 7 SEM mmHg and -30 +/- 5 mmHg). In mildly volume-depleted (normal salt diet and single injection of furosemide), conscious marmosets, H-142 and teprotide induced a similar fall in blood pressure (-14 +/- 4 mmHg and -15 +/- 2 mmHg). When H-142 was infused after the injection of teprotide, it had no further effect on blood pressure. Conversely, teprotide was ineffective when injected during the infusion of H-142. These results show that in marmosets blood pressure can be lowered by specific inhibitors of human renin. A converting-enzyme inhibitor has similar effects. Hence the renin-angiotensin system appears to contribute significantly to the maintenance of blood pressure in conscious, volume-depleted marmosets.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Hofbauer)
UniBasel Contributors:Hofbauer, Karl G.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Marcel Dekker
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:20
Deposited On:22 Mar 2012 13:20

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