Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome

Rinaldi, Andrea and Mian, Michael and Chigrinova, Ekaterina and Arcaini, Luca and Bhagat, Govind and Novak, Urban and Rancoita, Paola M. V. and De Campos, Cassio P. and Forconi, Francesco and Gascoyne, Randy D. and Facchetti, Fabio and Ponzoni, Maurilio and Govi, Silvia and Ferreri, Andrés J. M. and Mollejo, Manuela and Piris, Miguel A. and Baldini, Luca and Soulier, Jean and Thieblemont, Catherine and Canzonieri, Vincenzo and Gattei, Valter and Marasca, Roberto and Franceschetti, Silvia and Gaidano, Gianluca and Tucci, Alessandra and Uccella, Silvia and Tibiletti, Maria Grazia and Dirnhofer, Stephan and Tripodo, Claudio and Doglioni, Claudio and Dalla Favera, Riccardo and Cavalli, Franco and Zucca, Emanuele and Kwee, Ivo and Bertoni, Francesco. (2011) Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome. Blood, Vol. 117, H. 5. pp. 1595-1604.

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Official URL: http://edoc.unibas.ch/dok/A6005869

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Marginal zone B-cell lymphomas (MZLs) have been divided into 3 distinct subtypes (extranodal MZLs of mucosa-associated lymphoid tissue [MALT] type, nodal MZLs, and splenic MZLs). Nevertheless, the relationship between the subtypes is still unclear. We performed a comprehensive analysis of genomic DNA copy number changes in a very large series of MZL cases with the aim of addressing this question. Samples from 218 MZL patients (25 nodal, 57 MALT, 134 splenic, and 2 not better specified MZLs) were analyzed with the Affymetrix Human Mapping 250K SNP arrays, and the data combined with matched gene expression in 33 of 218 cases. MALT lymphoma presented significantly more frequently gains at 3p, 6p, 18p, and del(6q23) (TNFAIP3/A20), whereas splenic MZLs was associated with del(7q31), del(8p). Nodal MZLs did not show statistically significant differences compared with MALT lymphoma while lacking the splenic MZLs-related 7q losses. Gains of 3q and 18q were common to all 3 subtypes. del(8p) was often present together with del(17p) (TP53). Although del(17p) did not determine a worse outcome and del(8p) was only of borderline significance, the presence of both deletions had a highly significant negative impact on the outcome of splenic MZLs.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Histopathologie (Dirnhofer)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Histopathologie (Dirnhofer)
UniBasel Contributors:Dirnhofer, Stephan
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Society of Hematology
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:13 Sep 2013 07:59
Deposited On:13 Sep 2013 07:57

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