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Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis

Probstel, A. K. and Dornmair, K. and Bittner, R. and Sperl, P. and Jenne, D. and Magalhaes, S. and Villalobos, A. and Breithaupt, C. and Weissert, R. and Jacob, U. and Krumbholz, M. and Kuempfel, T. and Blaschek, A. and Stark, W. and Gartner, J. and Pohl, D. and Rostasy, K. and Weber, F. and Forne, I. and Khademi, M. and Olsson, T. and Brilot, F. and Tantsis, E. and Dale, R. C. and Wekerle, H. and Hohlfeld, R. and Banwell, B. and Bar-Or, A. and Meinl, E. and Derfuss, T.. (2011) Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis. Neurology, 77 (6). pp. 580-588.

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Official URL: http://edoc.unibas.ch/dok/A6003315

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Abstract

To study the longitudinal dynamics of anti-myelin oligodendrocyte glycoprotein (MOG) autoantibodies in childhood demyelinating diseases. METHODS: We addressed the kinetics of anti-MOG immunoglobulins in a prospective study comprising 77 pediatric patients. This was supplemented by a cross-sectional study analyzing 126 pediatric patients with acute demyelination and 62 adult patients with multiple sclerosis (MS). MOG-transfected cells were used for detection of antibodies by flow cytometry. RESULTS: Twenty-five children who were anti-MOG immunoglobulin (Ig) positive at disease onset were followed for up to 5 years. Anti-MOG antibodies rapidly and continuously declined in all 16 monophasic patients with acute disseminated encephalomyelitis and in one patient with clinically isolated syndrome. In contrast, in 6 of 8 patients (75%) eventually diagnosed with childhood MS, the antibodies to MOG persisted with fluctuations showing a second increase during an observation period of up to 5 years. Antibodies to MOG were mainly IgG 1 and their binding was largely blocked by pathogenic anti-MOG antibodies derived from a spontaneous animal model of autoimmune encephalitis. The cross-sectional part of our study elaborated that anti-MOG Ig was present in about 25% of children with acute demyelination, but in none of the pediatric or adult controls. Sera from 4/62 (6%) adult patients with MS had anti-MOG IgG at low levels. CONCLUSIONS: The persistence or disappearance of antibodies to MOG may have prognostic relevance for acute childhood demyelination.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Neurologie > Molekulare Neuroimmunologie (Derfuss)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Neurologie > Molekulare Neuroimmunologie (Derfuss)
03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Clinical Neuroimmunology (Derfuss/Lindberg)
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Neurologie > Neuroimmunologie (Kappos)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Neurologie > Neuroimmunologie (Kappos)
UniBasel Contributors:Derfuss, Tobias Johannes and Pröbstel, Anne-Katrin
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Academy of Neurology
ISSN:0028-3878
e-ISSN:1526-632X
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Oct 2017 10:25
Deposited On:13 Sep 2013 07:57

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