Reduced activity of locus coeruleus neurons in hypertensive rats

Olpe, H. R. and Berecek, K. H. and Jones, R. S. and Steinmann, M. W. and Sonnenburg, C. and Hofbauer, K. G.. (1985) Reduced activity of locus coeruleus neurons in hypertensive rats. Journal of Hypertension, Vol. 3, H. 4 , S93-S95.

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Official URL: http://edoc.unibas.ch/dok/A5258663

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The effect of blood pressure on the neuronal activity of the locus coeruleus (LC) was investigated by means of electrophysiological techniques in rats anaesthetized with chloral hydrate. The mean neuronal discharge rate of noradrenergic neurons of the LC was reduced by 19% in spontaneously hypertensive rats (SHR) and by 25% in deoxycorticosterone acetate (DOCA)-salt hypertensive rats compared with their corresponding controls. The cellular activity of 27 out of 40 neurons was reversibly suppressed by acute, peripherally induced blood pressure increases in normotensive rats. Five neurons were reversibly activated and eight neurons were not affected. Conversely, acute decreases in blood pressure stimulated the neuronal activity of the LC in 10 out of 16 neurons. These findings support the hypothesis of the LC having a role in both short and long term regulation of blood pressure.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Hofbauer)
UniBasel Contributors:Hofbauer, Karl G.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Lippincott Williams & Wilkins
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:20
Deposited On:22 Mar 2012 13:20

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