Intravascular lymphoma mimicking cerebral stroke : report of two cases

Hundsberger, Thomas and Cogliatti, Sergio and Kleger, Gian-Reto and Fretz, Christian and Gähler, Anita and Anliker, Mark and Fournier, Jean-Yves and von Moos, Roger and Tettenborn, Barbara and Driessen, Christoph. (2011) Intravascular lymphoma mimicking cerebral stroke : report of two cases. Case Reports in Neurology, 3 (3). pp. 278-283.

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Official URL: http://edoc.unibas.ch/dok/A6005475

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Ischemic stroke is a serious disease leading to significant morbidity and mortality. Multifocal and recurrent strokes are usually caused by embolic diseases, i.e. atrial fibrillation, but rare causes like cerebral vasculitis and clotting disorders are also well known. Here we report on two patients suffering from the very rare intravascular large B-cell lymphoma leading to multifocal and recurrent strokes in the brain and spinal cord as the prominent neurological symptom. The difficulties and the need for diagnostic brain biopsy in making an 'in vivo' diagnosis in this particular disease are outlined. Furthermore, the prerequisite for an interdisciplinary approach in these patients is strongly emphasized. Delayed diagnosis for several reasons was the most probable cause for cerebral relapse leading to death in one patient a few months after diagnosis. Conversely, early initiation of immunochemotherapy with a classical lymphoma schedule (R-CHOP) led to long-lasting remission of the disease in the other patient. With this report we like to improve alertness to intravascular large B-cell lymphoma as a cause for multifocal and recurrent strokes.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB
UniBasel Contributors:Cogliatti, Sergio Bruno
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Oct 2017 10:32
Deposited On:13 Sep 2013 07:57

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