Unconventional actin configurations step into the limelight

Silván, Unai and Jockusch, Brigitte M. and Schoenenberger, Cora-Ann. (2013) Unconventional actin configurations step into the limelight. Advances in protein chemistry and structural biology, Vol. 90. pp. 151-177.

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Official URL: http://edoc.unibas.ch/dok/A6165219

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The existence of a cellular machinery that is based on the reversible polymerization of globular nucleotide-bound protomers into polar microfilaments is a persistent feature from prokaryotes to higher vertebrates. However, while in bacteria, actin-like proteins with such properties have evolved into a large family with divergent sequences and polymeric structures, eukaryotes express only a small number of highly conserved actins. Indeed, the sequence of actin is one of the best conserved among eukaryotes and yet actin carries out many different functions at distinct cellular sites. Because of the notorious conservation and lack of suitable tools to examine structural plasticity, the vast majority of studies on cellular actin functions consider mainly two structural states, G-actin and F-actin. However, there is more to the structural plasticity of actin than first meets the eye. On one hand, more than 200 actin-binding proteins shape the conformation of actin and thereby regulate functional diversity. On the other hand, unconventional actin conformations that differ from monomeric G-actin are stepping into the limelight. In addition, supramolecular actin structures that extend beyond classical F-actin are emerging. Herein, we recapitulate the current knowledge on the structure and conformations of monomeric actin and its polymerization into higher order structures, paying special attention to less known forms and their involvement in actin function.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Schoenenberger)
UniBasel Contributors:Schoenenberger, Cora-Ann
Item Type:Article, refereed
Article Subtype:Research Article
Note:Also published in: Advances in protein chemistry and structural biology. Vol. 90, Organisation of chromosomes. - Amsterdam : Elsevier, 2013. - S. 151-177 -- Publication type according to Uni Basel Research Database: Journal article
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Last Modified:13 Sep 2013 07:59
Deposited On:13 Sep 2013 07:57

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