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How can plant DNA viruses evade siRNA-directed DNA methylation and silencing?

Pooggin, Mikhail. (2013) How can plant DNA viruses evade siRNA-directed DNA methylation and silencing? International journal of molecular sciences, Vol. 14, H. 8. pp. 15233-15259.

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Official URL: http://edoc.unibas.ch/dok/A6165022

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Abstract

Plants infected with DNA viruses produce massive quantities of virus-derived, 24-nucleotide short interfering RNAs (siRNAs), which can potentially direct viral DNA methylation and transcriptional silencing. However, growing evidence indicates that the circular double-stranded DNA accumulating in the nucleus for Pol II-mediated transcription of viral genes is not methylated. Hence, DNA viruses most likely evade or suppress RNA-directed DNA methylation. This review describes the specialized mechanisms of replication and silencing evasion evolved by geminiviruses and pararetoviruses, which rescue viral DNA from repressive methylation and interfere with transcriptional and post-transcriptional silencing of viral genes.
Faculties and Departments:05 Faculty of Science > Departement Umweltwissenschaften > Botanik > Pflanzenphysiologie Pathogenabwehr (Boller)
UniBasel Contributors:Pooggin, Mikhail
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Molecular Diversity Preservation International
ISSN:1422-0067
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:05 Dec 2014 09:45
Deposited On:13 Sep 2013 07:57

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