Pieters, Jean and Müller, Philipp and Jayachandran, Rajesh. (2013) On guard: coronin proteins in innate and adaptive immunity. Nature reviews. Immunology, Vol. 13, H. 7. pp. 510-518.
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Official URL: http://edoc.unibas.ch/dok/A6165349
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Abstract
Recent work has implicated members of the evolutionarily conserved family of coronin proteins - in particular coronin 1 - in immune homeostasis. Coronins are involved in processes as diverse as pathogen survival in phagocytes and homeostatic T cell signalling. Notably, in both mice and humans, coronin mutations are associated with immune deficiencies and resistance to autoimmunity. In this article, we review what is currently known about these conserved molecules and discuss a potential common mechanism that underlies their diverse activities, which seem to involve cytoskeletal interactions as well as calcium-calcineurin signalling.
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Infection Biology > Biochemistry (Pieters) |
|---|---|
| UniBasel Contributors: | Pieters, Jean |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Nature Publishing Group |
| ISSN: | 1474-1733 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Last Modified: | 13 Sep 2013 07:59 |
| Deposited On: | 13 Sep 2013 07:57 |
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