Diverging role for coronin 1 in antiviral CD4(+) and CD8(+) T cell responses

Tchang, Vincent Sam Yong and Mekker, Andrea and Siegmund, Kerstin and Karrer, Urs and Pieters, Jean. (2013) Diverging role for coronin 1 in antiviral CD4(+) and CD8(+) T cell responses. Molecular immunology, Vol. 56, H. 4. pp. 683-692.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6165351

Downloads: Statistics Overview


Coronin 1 is a member of the evolutionary conserved WD repeat protein family and is highly expressed in hematopoietic cells. Coronin 1 is essential for Ca(2+) mobilization upon T cell receptor (TCR) stimulation providing a pro-survival signal for naïve peripheral T cells. Both in mouse and in human, coronin 1 deficiency is associated with severe T cell lymphopenia. In this work, we have analyzed antiviral T cell-mediated immunity in the presence and absence of coronin 1 in vivo after infection with lymphocytic choriomenigitis virus (LCMV) and vesicular stomatitis virus (VSV) in mice. Despite low peripheral T cell numbers we found that LCMV-specific CD8(+) T cell responses were normal in the absence of coronin 1 and kinetics of LCMV-clearance were similar compared to wild type mice. In contrast, CD4(+) T cell responses were profoundly decreased after LCMV- and VSV-infection. We propose that coronin 1 plays a differential role in CD8(+) versus CD4(+) T cell responses and activation.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Biochemistry (Pieters)
UniBasel Contributors:Pieters, Jean
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Pergamon Press
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:13 Sep 2013 07:59
Deposited On:13 Sep 2013 07:56

Repository Staff Only: item control page