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Personalized cardiovascular medicine : concepts and methodological considerations

Völzke Henry, and Schmidt Carsten Oliver, and Baumeister Sebastian Edgar, and Ittermann Till, and Fung Glenn, and Krafczyk-Korth Janina, and Hoffmann Wolfgang, and Schwab Matthias, and Meyer zu Schwabedissen Henriette Elisabeth, and Dörr Marcus, and Felix Stefan, and Lieb Wolfgang, and Kroemer Heyo Klaus, . (2013) Personalized cardiovascular medicine : concepts and methodological considerations. Nature reviews. Cardiology, Vol. 10, H. 6. pp. 308-316.

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Official URL: http://edoc.unibas.ch/dok/A6164978

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Abstract

The primary goals of personalized medicine are to optimize diagnostic and treatment strategies by tailoring them to the specific characteristics of an individual patient. In this Review, we summarize basic concepts and methods of personalizing cardiovascular medicine. In-depth characterization of study participants and patients in general practice using standardized methods is a pivotal component of study design in personalized medicine. Standardization and quality assurance of clinical data are similarly important, but in daily practice imprecise definitions of clinical variables can reduce power and introduce bias, which limits the validity of the data obtained as well as their potential clinical applicability. Changes in statistical methods with personalized medicine include a shift from dichotomous outcomes towards continuously measured variables, predictive modelling, and individualized medical decisions, subgroup analyses, and data-mining strategies. A variety of approaches to personalized medicine exist in cardiovascular research and clinical practice that might have the potential to individualize diagnostic and therapeutic procedures. For some of the emerging methods, such as data mining, the most-efficient way to use these tools is not yet fully understood. In addition, the predictive models-although promising-are far from mature, and are likely to be greatly improved by using available large-scale data sets.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Biopharmazie (Meyer zu Schwabedissen)
UniBasel Contributors:Meyer zu Schwabedissen, H.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature Publishing Group
ISSN:1759-5002
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:13 Sep 2013 07:59
Deposited On:13 Sep 2013 07:56

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