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Dynamics of anemia in relation to parasitic infections, micronutrient status, and growing age in south-central Côte d'Ivoire

Righetti, A. A. and Adiossan, L. G. and Ouattara, M. and Glinz, D. and Hurrell, R. F. and N'Goran, E. K. and Wegmuller, R. and Utzinger, J.. (2013) Dynamics of anemia in relation to parasitic infections, micronutrient status, and growing age in south-central Côte d'Ivoire. Journal of infectious diseases, Vol. 207, no. 10. pp. 1604-1615.

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Official URL: http://edoc.unibas.ch/dok/A6124603

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Abstract

Background. Parasitic diseases (e.g., malaria and helminthiases) exert enormous burdens on public health and social wellbeing. Moreover, parasitic infections are important causes of anemia in tropical Africa, exacerbated by lack of diversified diet, inflammatory and genetic diseases. There is a paucity of longitudinal studies monitoring the dynamics of anemia in relation to the aforementioned parameters.Methods. We designed a 14-month prospective longitudinal study in three cohorts (i.e., infants aged 6-23 months, 6-8 year-old children, and women aged 15-25 years), in the Taabo health demographic surveillance system located in south-central Cote d'Ivoire. Parasitological, hematological, and micronutrient data were obtained at repeated cross-sectional surveys, utilizing standardized, quality-controlled methods.Results. We found that young age, Plasmodium and Schistosoma infections, cellular iron deficiency, and stunting were significantly negatively associated with hemoglobin concentration. Moreover, iron status biomarkers (i.e., ferritin and soluble transferrin receptor) were significantly associated with inflammatory parameters.Conclusions. Our results call for effective prevention and control measures targeting parasitic diseases and iron deficiency. These measures might include the distribution of long-lasting insecticidal nets, intermittent preventive treatment for malaria, regular anthelmintic drug administration, and improved intake of bioavailable iron, coupled with health and nutritional education, improved hygiene, water, and sanitation
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Eco System Health Sciences > Health Impact Assessment (Utzinger)
UniBasel Contributors:Utzinger, Jürg
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Oxford University Press
ISSN:0022-1899
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:13 Sep 2013 07:59
Deposited On:13 Sep 2013 07:49

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