Metastatic colon cancer cells negotiate the intravasation notch

Christofori, Gerhard. (2011) Metastatic colon cancer cells negotiate the intravasation notch. Cancer cell, Vol. 19, H. 1. pp. 6-8.

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Official URL: http://edoc.unibas.ch/dok/A6006418

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In this issue of Cancer Cell, Sonoshita et al. report that Aes/Grg5 prevents metastasis of colorectal cancer cells by sequestering and inactivating Notch transcriptional effectors in distinct nuclear foci. Loss of Aes/Grg5 in invasive cancer cells where Notch is activated by stroma-expressed ligands promotes invasion, transendothelial migration, intravasation, and metastasis.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Tumor Biology (Christofori)
UniBasel Contributors:Christofori, Gerhard M.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Cell Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Apr 2015 09:13
Deposited On:13 Sep 2013 07:49

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