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Ambiguous nucleotide calls from population-based sequencing of HIV-1 are a marker for viral diversity and the age of infection

Kouyos, R. D. and von Wyl, V. and Yerly, S. and Boni, J. and Rieder, P. and Joos, B. and Taffe, P. and Shah, C. and Burgisser, P. and Klimkait, T. and Weber, R. and Hirschel, B. and Cavassini, M. and Rauch, A. and Battegay, M. and Vernazza, P. L. and Bernasconi, E. and Ledergerber, B. and Bonhoeffer, S. and Gunthard, H. F. and Swiss HIV Cohort Study, . (2011) Ambiguous nucleotide calls from population-based sequencing of HIV-1 are a marker for viral diversity and the age of infection. Clinical infectious diseases, Vol. 52, H. 4. pp. 532-539.

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Official URL: http://edoc.unibas.ch/dok/A6005417

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Abstract

The time passed since the infection of a human immunodeficiency virus (HIV)-infected individual (the age of infection) is an important but often only poorly known quantity. We assessed whether the fraction of ambiguous nucleotides obtained from bulk sequencing as done for genotypic resistance testing can serve as a proxy of this parameter.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Infection Biology (Khanna)
03 Faculty of Medicine > Departement Biomedizin > Division of Medical Microbiology > Molecular Virology (Klimkait)
UniBasel Contributors:Klimkait, Thomas and Battegay, Manuel E.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Oxford University Press
ISSN:1058-4838
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Apr 2015 09:13
Deposited On:16 Aug 2013 07:33

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