Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque

Rotger, Margalida and Dalmau, Judith and Rauch, Andri and McLaren, Paul and Bosinger, Steven E. and Martinez, Raquel and Sandler, Netanya G. and Roque, Annelys and Liebner, Julia and Battegay, Manuel and Bernasconi, Enos and Descombes, Patrick and Erkizia, Itziar and Fellay, Jacques and Hirschel, Bernard and Miró, Jose M. and Palou, Eduard and Hoffmann, Matthias and Massanella, Marta and Blanco, Julià and Woods, Matthew and Günthard, Huldrych F. and de Bakker, Paul and Douek, Daniel C. and Silvestri, Guido and Martinez-Picado, Javier and Telenti, Amalio. (2011) Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque. Journal of Clinical Investigation, Vol. 121, H. 6. pp. 2391-2400.

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Official URL: http://edoc.unibas.ch/dok/A6005415

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High levels of HIV-1 replication during the chronic phase of infection usually correlate with rapid progression to severe immunodeficiency. However, a minority of highly viremic individuals remains asymptomatic and maintains high CD4? T cell counts. This tolerant profile is poorly understood and reminiscent of the widely studied nonprogressive disease model of SIV infection in natural hosts. Here, we identify transcriptome differences between rapid progressors (RPs) and viremic nonprogressors (VNPs) and highlight several genes relevant for the understanding of HIV-1-induced immunosuppression. RPs were characterized by a specific transcriptome profile of CD4? and CD8? T cells similar to that observed in pathogenic SIV-infected rhesus macaques. In contrast, VNPs exhibited lower expression of interferon-stimulated genes and shared a common gene regulation profile with nonpathogenic SIV-infected sooty mangabeys. A short list of genes associated with VNP, including CASP1, CD38, LAG3, TNFSF13B, SOCS1, and EEF1D, showed significant correlation with time to disease progression when evaluated in an independent set of CD4? T cell expression data. This work characterizes 2 minimally studied clinical patterns of progression to AIDS, whose analysis may inform our understanding of HIV pathogenesis.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Infection Biology (Khanna)
UniBasel Contributors:Battegay, Manuel E.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Society for Clinical Investigation
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:13 Oct 2017 08:21
Deposited On:16 Aug 2013 07:33

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