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The role of migration and domestic transmission in the spread of HIV-1 non-B subtypes in Switzerland

von Wyl, Viktor and Kouyos, Roger D. and Yerly, Sabine and Böni, Jürg and Shah, Cyril and Bürgisser, Philippe and Klimkait, Thomas and Weber, Rainer and Hirschel, Bernard and Cavassini, Matthias and Staehelin, Cornelia and Battegay, Manuel and Vernazza, Pietro L. and Bernasconi, Enos and Ledergerber, Bruno and Bonhoeffer, Sebastian and Günthard, Huldrych F. and Swiss HIV Cohort Study, . (2011) The role of migration and domestic transmission in the spread of HIV-1 non-B subtypes in Switzerland. Journal of infectious diseases, Vol. 204, no. 7. pp. 1095-1103.

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Official URL: http://edoc.unibas.ch/dok/A6004089

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Abstract

Background. By analyzing human immunodeficiency virus type 1 (HIV-1) pol sequences from the Swiss HIV Cohort Study (SHCS), we explored whether the prevalence of non-B subtypes reflects domestic transmission or migration patterns. Methods. Swiss non-B sequences and sequences collected abroad were pooled to construct maximum likelihood trees, which were analyzed for Swiss-specific subepidemics, (subtrees including <= 80% Swiss sequences, bootstrap < 70%; macroscale analysis) or evidence for domestic transmission (sequence pairs with genetic distance = 98%; microscale analysis). Results. Of 8287 SHCS participants, 1732 (21%) were infected with non-B subtypes, of which A (n = 328), C (n = 272), CRF01_AE (n = 258), and CRF02_AG (n = 285) were studied further. The macroscale analysis revealed that 21% (A), 16% (C), 24% (CRF01_AE), and 28% (CRF02_AG) belonged to Swiss-specific subepidemics. The microscale analysis identified 26 possible transmission pairs: 3 (12%) including only homosexual Swiss men of white ethnicity; 3 (12%) including homosexual white men from Switzerland and partners from foreign countries; and 10 (38%) involving heterosexual white Swiss men and females of different nationality and predominantly nonwhite ethnicity. Conclusions. Of all non-B infections diagnosed in Switzerland, > 25% could be prevented by domestic interventions. Awareness should be raised among immigrants and Swiss individuals with partners from high prevalence countries to contain the spread of non-B subtypes.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Infection Biology (Khanna)
03 Faculty of Medicine > Departement Biomedizin > Division of Medical Microbiology > Molecular Virology (Klimkait)
UniBasel Contributors:Klimkait, Thomas and Battegay, Manuel E.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Oxford University Press
ISSN:0022-1899
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Apr 2015 09:13
Deposited On:16 Aug 2013 07:32

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