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[(η(6) -praziquantel)Cr(CO)(3)] derivatives with remarkable in vitro anti-schistosomal activity

Patra, M. and Ingram, K. and Pierroz, V. and Ferrari, S. and Spingler, B. and Gasser, R. B. and Keiser, J. and Gasser, G.. (2013) [(η(6) -praziquantel)Cr(CO)(3)] derivatives with remarkable in vitro anti-schistosomal activity. Chemistry : a European journal, Vol. 19, H. 7. pp. 2232-2235.

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Official URL: http://edoc.unibas.ch/dok/A6124613

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Abstract

The antischistosomal effect of two [(eta(6) -praziquantel)Cr(CO)(3) ] derivatives 1 and 2 was investigated. The compounds (see figure: Cr purple, N blue, O red) are prepared in a one-step procedure from commercially available praziquantel. Both derivatives show a high in vitro activity against Schistosoma mansoni, a parasitic trematode, and had only a minor cytotoxic effect on selected mammalian cell lines
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Helminth Drug Development (Keiser)
UniBasel Contributors:Keiser, Jennifer
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley-VCH Verlag
ISSN:0947-6539
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:16 Aug 2013 07:34
Deposited On:16 Aug 2013 07:31

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