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Cytokine production by islets in health and diabetes : cellular origin, regulation and function

Donath, Marc Y. and Böni-Schnetzler, Marianne and Ellingsgaard, Helga and Halban, Philippe A. and Ehses, Jan A.. (2010) Cytokine production by islets in health and diabetes : cellular origin, regulation and function. Trends in endocrinology and metabolism, Vol. 21, no. 5. pp. 261-267.

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Official URL: http://edoc.unibas.ch/dok/A6007732

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Abstract

Islets produce a variety of cytokines and chemokines in response to physiologic and pathologic stimulation by nutrients. The cellular source of these inflammatory mediators includes alpha-, beta-, endothelial-, ductal- and recruited immune cells. Islet-derived cytokines promote alpha- and beta-cell adaptation and repair in the short term. Eventually, chronic metabolic stress can induce a deleterious autoinflammatory process in islets leading to insulin secretion failure and type 2 diabetes. Understanding the specific role of islet derived cytokines and chemokines has opened the door to targeted clinical interventions aimed at remodeling islet inflammation from destruction to adaptation. In this article, we review the islet cellular origin of various cytokines and chemokines and describe their regulation and respective roles in physiology and diabetes.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Infection Biology (Khanna)
UniBasel Contributors:Donath, Marc
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Elsevier Science
ISSN:1043-2760
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:16 Aug 2013 07:34
Deposited On:16 Aug 2013 07:31

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