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Axo-glial antigens as targets in multiple sclerosis : implications for axonal and grey matter injury

Derfuss, Tobias and Linington, Chris and Hohlfeld, Reinhard and Meinl, Edgar. (2010) Axo-glial antigens as targets in multiple sclerosis : implications for axonal and grey matter injury. Journal of molecular medicine, Vol. 88, no. 8. pp. 753-761.

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Official URL: http://edoc.unibas.ch/dok/A6007504

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Abstract

Multiple sclerosis is thought to be an autoimmune-mediated disease of the central nervous system. For many years, T-cells were regarded as the key players in the pathogenesis, and myelin of white matter was considered as the main victim. However, research during recent years showed a more complex picture. Besides T-cells, also B-cells, antibodies and the innate immunity contribute to the tissue damage. Modern imaging techniques and neuropathological examinations showed that not only myelin but also axons, cortical neurons and nodes of Ranvier are damaged. The autoimmune targets of this widespread injury are so far not known. The identification of the axo-glial proteins contactin-2 and neurofascin provides excellent examples how antibodies can induce axonal injury at the node of Ranvier and how T-cells can destruct cortical integrity. This review will discuss the pathogenic implications of an autoimmune response against these newly discovered antigens.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Clinical Neuroimmunology (Derfuss/Lindberg)
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Neurologie > Molekulare Neuroimmunologie (Derfuss)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Neurologie > Molekulare Neuroimmunologie (Derfuss)
UniBasel Contributors:Derfuss, Tobias Johannes
Item Type:Article, refereed
Article Subtype:Review Article
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:0946-2716
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:16 Aug 2013 07:34
Deposited On:16 Aug 2013 07:30

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