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Single domain response regulators : molecular switches with emerging roles in cell organization and dynamics

Jenal, U. and Galperin, M. Y.. (2009) Single domain response regulators : molecular switches with emerging roles in cell organization and dynamics. Current Opinion in Microbiology, Vol. 12, H. 2. pp. 152-160.

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Official URL: http://edoc.unibas.ch/dok/A5258534

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Abstract

Single domain response regulators (SD-RRs) are signaling components of two-component phosphorylation pathways that harbor a phosphoryl receiver domain but lack a dedicated output domain. The Escherichia coli protein CheY, the paradigm member of this family, regulates chemotaxis by relaying information between chemoreceptors and the flagellar motor switch. New data provide a more complex picture of CheY-mediated motility control in several bacteria and suggest diverging mechanisms in control of cellular motors. Moreover, advances have been made in understanding cellular functions of SD-RRs beyond chemotaxis. We review recent reports indicating that SD-RRs constitute a family of versatile molecular switches that contribute to cellular organization and dynamics as spatial organizer and/or as allosteric regulators of histidine protein kinases.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Molecular Microbiology (Jenal)
05 Faculty of Science > Departement Biozentrum > Growth & Development > Molecular Microbiology (Jenal)
UniBasel Contributors:Jenal, Urs
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1369-5274
e-ISSN:1879-0364
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:13 Oct 2017 07:52
Deposited On:22 Mar 2012 13:20

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