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Occupational exposure to dusts, gases and fumes and incidence of chronic obstructive pulmonary disease in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults

Mehta, A. J. and Miedinger, D. and Keidel, D. and Bettschart, R. and Bircher, A. and Bridevaux, P. O. and Curjuric, I. and Kromhout, H. and Rochat, T. and Rothe, T. and Russi, E. W. and Schikowski, T. and Schindler, C. and Schwartz, J. and Turk, A. and Vermeulen, R. and Probst-Hensch, N. and Künzli, N.. (2012) Occupational exposure to dusts, gases and fumes and incidence of chronic obstructive pulmonary disease in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults. American journal of respiratory and critical care medicine : an official journal of the American Thoracic Society, Vol. 185, H. 12. pp. 1292-1300.

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Official URL: http://edoc.unibas.ch/dok/A6094300

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Abstract

RATIONALE: There is limited evidence from population-based studies demonstrating incidence of spirometric-defined chronic obstructive pulmonary disease (COPD) in association with occupational exposures. OBJECTIVES: We evaluated the association between occupational exposures and incidence of COPD in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA). MEASUREMENTS AND MAIN RESULTS: Pre-bronchodilator ratio of forced expiratory volume in one second over forced vital capacity (FEV(1)/FVC) was measured in 4,267 non-asthmatic SAPALDIA participants ages 18-62 at baseline in 1991 and at follow-up in 2001-2003. COPD was defined by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criterion (FEV(1)/FVC/=80% and /=40 years, and remained elevated when restricted to non-smokers. CONCLUSIONS: In a Swiss working adult population, occupational exposures to biological dusts, mineral dusts, gases/fumes, and VGDF were associated with incidence of COPD of at least moderate severity
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology
UniBasel Contributors:Schindler, Christian and Keidel, Dirk and Curjuric, Ivan and Künzli, Nino and Probst Hensch, Nicole and Schikowski, Tamara
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Thoracic Society
ISSN:0003-0805
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:16 Aug 2013 07:34
Deposited On:16 Aug 2013 07:28

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