FLOTAC for the diagnosis of Hymenolepis spp. infection : proof-of-concept and comparing diagnostic accuracy with other methods

Steinmann, Peter and Cringoli, Giuseppe and Bruschi, Fabrizio and Matthys, Barbara and Lohourignon, Laurent K. and Castagna, Barbara and Maurelli, Maria P. and Morgoglione, Maria E. and Utzinger, Jürg and Rinaldi, Laura. (2012) FLOTAC for the diagnosis of Hymenolepis spp. infection : proof-of-concept and comparing diagnostic accuracy with other methods. Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie, Vol. 111, H. 2. pp. 749-754.

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Official URL: http://edoc.unibas.ch/dok/A6094181

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Hymenolepis nana is the most common cestode parasitizing humans, yet it is under-diagnosed. We determined the optimal flotation solution (FS) for the diagnosis of this intestinal parasite with the FLOTAC method, and compared its diagnostic accuracy with an ether-concentration technique and the Kato-Katz method. Zinc sulphate (specific gravity 1.20) proved to be the best-performing FS. Using this FS, we detected 65 H. nana infections among 234 fixed fecal samples from Tajik and Sahrawi children (prevalence 27.8 %). The ether-concentration technique detected 40 infections (prevalence 17.1 %) in the same samples. Considering the combined results as a reference, the sensitivities of FLOTAC and ether-concentration were 95.6 % and 58.8 %, respectively. The Kato-Katz method resulted in a prevalence of only 8.7 %. In terms of eggs per gram of stool, a significantly (P >0.05) higher value was obtained with the FLOTAC and Kato-Katz techniques compared to ether-concentration. In another study carried out in China, the FLOTAC method detected six Hymenolepis diminuta infections in 302 fecal samples, whereas five samples were found positive with the Kato-Katz technique. We conclude that FLOTAC is an accurate coprodiagnostic technique for H. nana and H. diminuta, two species which join a growing list of intestinal parasites that can be reliably diagnosed by this technique
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Eco System Health Sciences
UniBasel Contributors:Utzinger, Jürg and Steinmann, Peter
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Sep 2015 14:31
Deposited On:19 Jul 2013 07:43

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