Exploring prospects of novel drugs for tuberculosis

Janssen, S. and Jayachandran, R. and Khathi, L. and Zinsstag, J. and Grobusch, M. P. and Pieters, J.. (2012) Exploring prospects of novel drugs for tuberculosis. Drug design, development and therapy, 6. pp. 217-224.

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Official URL: http://edoc.unibas.ch/dok/A6094169

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Tuberculosis remains a disease with an enormous impact on public health worldwide. With the continuously increasing epidemic of drug-resistant tuberculosis, new drugs are desperately needed. However, even for the treatment of drug-sensitive tuberculosis, new drugs are required to shorten the treatment duration and thereby prevent development of drug resistance. Within the past ten years, major advances in tuberculosis drug research have been made, leading to a considerable number of antimycobacterial compounds which are now in the pipeline. Here we discuss a number of these novel promising tuberculosis drugs, as well as the discovery of two new potential drug targets for the development of novel effective drugs to curb the tuberculosis pandemic, ie, the coronin 1 and protein kinase G pathways. Protein kinase G is secreted by mycobacteria and is responsible for blocking lysosomal delivery within the macrophage. Coronin 1 is responsible for activating the phosphatase, calcineurin, and thereby preventing phagosome-lysosome fusion within the macrophage. Blocking these two pathways may lead to rapid killing of mycobacteria
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Biochemistry (Pieters)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Human and Animal Health
UniBasel Contributors:Zinsstag, Jakob Z and Pieters, Jean and Jayachandran, Rajesh
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Dove Medical Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:27 Sep 2017 12:14
Deposited On:19 Jul 2013 07:43

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