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Screening of antifungal azole drugs and agrochemicals with an adapted Alamar Blue-based assay demonstrates antibacterial activity of Croconazole against Mycobacterium ulcerans

Scherr, N. and Röltgen, K. and Witschel, M. and Pluschke, G.. (2012) Screening of antifungal azole drugs and agrochemicals with an adapted Alamar Blue-based assay demonstrates antibacterial activity of Croconazole against Mycobacterium ulcerans. Antimicrobial agents and chemotherapy, Vol. 56, H. 12. pp. 6410-6413.

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Official URL: http://edoc.unibas.ch/dok/A6094358

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Abstract

An Alamar Blue-based growth inhibition assay has been adapted for the thermosensitive and slow growing pathogen Mycobacterium ulcerans (M. ulcerans). The standardized test procedure enables medium-throughput screening of pre-selected compound libraries. Testing of a set of 48 azoles with known antifungal activity led to the identification of an imidazole antifungal displaying an inhibitory dose (ID) of 9 muM for M. ulcerans
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Molecular Immunology (Pluschke)
UniBasel Contributors:Pluschke, Gerd
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Society for Microbiology
ISSN:0066-4804
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:19 Jul 2013 07:44
Deposited On:19 Jul 2013 07:42

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