CDC48 function during TMV infection: Regulation of virus movement and replication by degradation?

Niehl, Annette and Amari, Khalid and Heinlein, Manfred. (2013) CDC48 function during TMV infection: Regulation of virus movement and replication by degradation? Plant signaling & behavior, Vol. 8 , e22865.

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Official URL: http://edoc.unibas.ch/dok/A6146278

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Cell-division-cycle protein 48 (CDC48) is an essential, conserved ATP-driven chaperone in eukaryotic cells, which functions in diverse cellular processes including the targeting of misfolded and aggregated proteins for degradation via proteasomal and aggresomal-autophagic pathways. We recently demonstrated that plant CDC48 localizes to and interacts with Tobacco mosaic virus (TMV) movement protein (MP) in ER-associated viral protein inclusions. Our data suggest that CDC48 participates in the clearance of these viral protein inclusions in an ER-assisted protein degradation (ERAD)-like mechanism. As TMV MP-inclusions formed at late infection stages resemble aggresomes, we here propose that TMV MP enters both, ERAD-like and aggresomal pathways in its host cells and that CDC48 coordinates these processes. Moreover, as viruses often exploit host pathways for replication and spread, we propose a model in which CDC48 functions in the degradation pathway of overaccumulating viral protein and also actively participates in the regulation of TMV replication and cell-to-cell movement.
Faculties and Departments:05 Faculty of Science > Departement Umweltwissenschaften > Integrative Biologie
UniBasel Contributors:Heinlein, Manfred and Amari, Khalid and Niehl, Annette
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Landes Bioscience
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:19 Jul 2013 07:44
Deposited On:19 Jul 2013 07:42

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