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Danger signs in drug hypersensitivity

Scherer, Kathrin and Bircher, Andreas J.. (2010) Danger signs in drug hypersensitivity. The medical clinics of North America, Vol. 94, no. 4. pp. 681-689.

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Official URL: http://edoc.unibas.ch/dok/A6007491

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Abstract

ADRs are frequently considered iatrogenic complications and, therefore, pose a specific challenge for the physician-patient relationship. Early recognition of a potential ADR is possible, especially on the skin, in addition to characteristic clinical danger signs. Cutaneous manifestations are variable, depending on the causative pathomechanism. It is impossible to conclude the causative agent from the morphology of the cutaneous lesions. The intake of several drugs in the time before the elicitation of the drug reaction usually poses a diagnostic challenge. It is crucial for the precision of any further allergological work-up to document the type of rash precisely as well as the time course of drug intake and appearance of the first symptoms. involvement of internal organs or circulating blood cells. Timely recognition of such cutaneous lesions and the correct differential diagnosis with prompt withdrawal of the putative culprit drug are essential to reducing morbidity and preventing mortality. This article discusses risk factors, early symptoms, and danger signs indicating a possibly severe course of an ADR and advises on early actions.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Dermatologie (Bircher)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Dermatologie (Bircher)
UniBasel Contributors:Bircher, Andreas J.
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Saunders
ISSN:0025-7125
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:19 Jul 2013 07:44
Deposited On:19 Jul 2013 07:41

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