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PM10 and children's respiratory symptoms and lung function in the PATY study

Hoek, G. and Pattenden, S. and Willers, S. and Antova, T. and Fabianova, E. and Braun-Fahrländer, C. and Forastiere, F. and Gehring, U. and Luttmann-Gibson, H. and Grize, L. and Heinrich, J. and Houthuijs, D. and Janssen, N. and Katsnelson, B. and Kosheleva, A. and Moshammer, H. and Neuberger, M. and Privalova, L. and Rudnai, P. and Speizer, F. and Slachtova, H. and Tomaskova, H. and Zlotkowska, R. and Fletcher, T.. (2012) PM10 and children's respiratory symptoms and lung function in the PATY study. The European respiratory journal, 40 (3). pp. 538-547.

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Official URL: http://edoc.unibas.ch/dok/A6094317

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Abstract

Studies of the impact of long-term exposure to outdoor air pollution on prevalence of respiratory symptoms and lung function in children have yielded mixed results, partly related to differences in study design, exposure assessment, confounder selection and data analysis.We assembled respiratory health and exposure data for more than 45,000 children from comparable cross-sectional studies in 12 countries. Eleven respiratory symptoms were selected for which comparable questions were asked. Spirometry was performed in about half of the children. Exposure to air pollution was mainly characterized by annual average concentrations of particulate matter smaller than 10 mum (PM10) measured at fixed sites within the study areas.Positive associations were found between the average PM10 concentration and the prevalence of phlegm (Odds Ratio per 10 mug.m(-3) 1.15, 95% Confidence Interval 1.02-1.30), hay fever (1.20 (0.99-1.46)), bronchitis (1.08 (0.98-1.19)), morning cough (1.15 (1.02-1.29)) and nocturnal cough (1.13 (0.98-1.29)). There were no associations with diagnosed asthma and asthma symptoms. PM10 was not associated with lung function across all studies combined.Our study adds to the evidence that long-term exposure to outdoor air pollution, characterized by the concentration of PM10, is associated with increased respiratory symptoms
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health
UniBasel Contributors:Braun-Fahrländer, Charlotte and Grize, Leticia
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Munksgaard
ISSN:0903-1936
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:27 Oct 2017 09:36
Deposited On:19 Jul 2013 07:37

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