Cell-free DNA in the circulation as a potential cancer biomarker

Kohler, Corina and Barekati, Zeinab and Radpour, Ramin and Zhong, Xiao Yan. (2011) Cell-free DNA in the circulation as a potential cancer biomarker. Anticancer research, Vol. 31, H. 8. pp. 2623-2628.

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Official URL: http://edoc.unibas.ch/dok/A6007483

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In the course of the search for new biomarkers, circulating cell-free DNA (ccf-DNA) has become a popular target of interest. An elevated level of ccf-DNA has been detected in the circulation of cancer patients in comparison with healthy controls. Since ccf-DNA in cancer patients often bears similar genetic and epigenetic features to the related tumor DNA, there is evidence that some of the ccf-DNA originates from tumoral tissue. This, and the fact that ccf-DNA can easily be isolated from the circulation and other body fluids of patients, makes it a promising candidate as a non-invasive biomarker of cancer. Yet ccf-DNA-based cancer tests have not come to fruitful clinical applications. This review evaluates the potential of ccf-DNA alterations as a biomarker for cancer management by addressing the question of how large the gap between ccf-DNA and the ideal cancer biomarker is.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Gynecological Oncology (Zhong)
UniBasel Contributors:Zhong, Xiao Yan
Item Type:Article, refereed
Article Subtype:Book Review
Bibsysno:Link to catalogue
Publisher:Potamitis Press
Note:Publication type according to Uni Basel Research Database: Journal item
Last Modified:19 Jul 2013 07:43
Deposited On:19 Jul 2013 07:37

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