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Endocytotic segregation of gliadin peptide 31-49 in enterocytes

Zimmer, Klaus-Peter and Fischer, Ina and Mothes, Thomas and Weissen-Plenz, Gabriele and Schmitz, Martina and Wieser, Herbert and Büning, Jürgen and Lerch, Markus M. and Ciclitira, Paul C. and Weber, Peter and Naim, Hassan Y.. (2010) Endocytotic segregation of gliadin peptide 31-49 in enterocytes. Gut, Vol. 59, H. 2. pp. 300-310.

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Official URL: http://edoc.unibas.ch/dok/A6006855

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Abstract

Coeliac disease (CD) is a multisystemic autoimmune inflammation of the intestinal tract induced by wheat gluten and related cereals in human leucocyte antigen (HLA)-DQ2/8-positive individuals. The molecular mechanisms relevant to oral tolerance induction towards toxic cereals such as gliadin remain poorly understood. Enterocytes, which express predominantly HLA-DR proteins, are capable of processing, transcytosing and presenting food antigens from the intestinal lumen to T lymphocytes of the lamina propria.
Faculties and Departments:03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Neuro- und Entwicklungspädiatrie (Weber)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Neuro- und Entwicklungspädiatrie (Weber)
UniBasel Contributors:Weber, Peter
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:British Medical Association
ISSN:0017-5749
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:19 Jul 2013 07:43
Deposited On:19 Jul 2013 07:34

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