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Role of pyrimidine depletion in the mitochondrial cardiotoxicity of nucleoside analogue reverse transcriptase inhibitors

Balcarek, Kerstin and Venhoff, Nils and Deveaud, Catherine and Beauvoit, Bertrand and Bonnet, Jacques and Kirschner, Janbernd and Venhoff, Ana C. and Lebrecht, Dirk and Walker, Ulrich A.. (2010) Role of pyrimidine depletion in the mitochondrial cardiotoxicity of nucleoside analogue reverse transcriptase inhibitors. JAIDS: journal of acquired immune deficiency syndromes, Vol. 55, H. 5. pp. 550-557.

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Official URL: http://edoc.unibas.ch/dok/A6005987

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Abstract

Long-term antiretroviral treatment with nucleoside analogue reverse transcriptase inhibitors (NRTI) may result in a cardiomyopathy due to mitochondrial DNA (mtDNA) depletion. An intact mitochondrial function is required for the synthesis of intramyocardial pyrimidine nucleotides, which in turn are building blocks of mtDNA. We investigated if NRTI-related cardiomyopathy can be prevented with pyrimidine precursors.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Rheumatologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Rheumatologie
UniBasel Contributors:Walker, Ulrich A.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Lippincott Williams & Wilkins
ISSN:1525-4135
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:21 Jun 2013 12:29
Deposited On:21 Jun 2013 12:28

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