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Microsomal triacylglycerol transfer protein (MTP) is required cell autonomously to expand tracheal lumen in Drosophila

Baer, Magdalena M. and Palm, Wilhelm and Eaton, Suzanne and Leptin, Maria and Affolter, Markus. (2012) Microsomal triacylglycerol transfer protein (MTP) is required cell autonomously to expand tracheal lumen in Drosophila. Journal of cell science, Vol. 125, H. 24. pp. 6038-6048.

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Official URL: http://edoc.unibas.ch/dok/A6043762

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Abstract

The Drosophila tracheal system has been a useful model to dissect the molecular mechanisms controlling the assembly and expansion of tubular organs. We have identified Microsomal triacylglycerol transfer protein (MTP) as a new player involved in the lumen expansion in unicellular tubes. MTP is an Endoplasmic Reticulum resident protein that can transfer triglycerides and phospholipids between membranes in vitro. MTP lipid transfer activity is crucial for the assembly and secretion of apoB family lipoproteins, which are carriers of lipids between different tissues. Here we describe an unexpected role of MTP in tracheal development, which we postulate to be independent of its known function in lipoprotein secretion. We propose that in tracheal cells MTP is involved in regulation of de novo apical membrane delivery to the existing lumen and thus promotes proper expansion of the larval tracheal system.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell Biology (Affolter)
UniBasel Contributors:Affolter, Markus
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Company of Biologists
ISSN:0021-9533
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:21 Jun 2013 12:29
Deposited On:21 Jun 2013 12:27

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